The minimum quantity of lubricant technique in grinding of steel using a wheel cleaning system

The application of minimum quantity of lubricant (MQL) for metal cutting has emerged as an alternative for reducing the abundant flow of cutting fluids, thus achieving cleaner production. Although considered an innovative technique in grinding operations, the widespread application is hindered mainly due to the high heat generation and the clogging of wheel pores caused by machined chips, harming the final product quality and increasing tool wear. This study sought to improve MQL use in grinding. Thus, besides the conventional MQL injected at the wheel/workpiece interface, a compressed air jet was also added, in order to clean the clogged wheel pores from the mixture of MQL oil and machined chips. Experiments were conducted using external cylindrical plunge grinding on AISI 4340 quenched and tempered steel, and a vitrified cubic boron nitrite (CBN) wheel. The lubri-refrigeration methods employed were the conventional with abundant flow, conventional MQL (both without any cleaning air jets) and MQL with the cleaning jet, directed at the surface at different angles of incidence. The main goal of these experiments was to verify the viability of replacing traditional abundance flow with MQL with wheel cleaning. The analyses were conducted by measuring the following output variables of the process: workpiece surface roughness, roundness, diametrical wear of the wheel. Results show the possibility of implementing the cleaning jet technique as a technological improvement of the minimum quantity of and grinding, in order to reduce the usage of cutting fluids. The MQL technique with cleaning compressed air jet, for a specific angle of incidence (30°) proved to be extremely efficient to obtain improved surface quality and accurate workpiece shape, as well as to reduce wear wheel and to prevent thermal damage, when compared to the other lubri-refrigeration methods tested (without cleaning jet).Special thanks to FAPESP (State of São Paulo Research Assistance Foundation) (process 2009/51440-5 (Research Assistance) and 2009/51439-7 (Scientific Initiation)) for the financial resources made available for this study, and to the Schaeffler Group (INA brand) for the support offered in conducting metallographic analyses

Analysis of the influence of the different times of polymerization by incandescent light in composite resins by evaluation of its abrasive wear

No mercado atual a qualidade é necessária na fabricação dos produtos. No mercado odontológico, as resinas compostas são cada vez mais utilizadas para substituir materiais tradicionais, como amalgama, nas restaurações estéticas e funcionais, apresentando boa estética e funcionalidade. A composição química destes materiais é variável e os resultados das reações químicas do processo de polimerização são bastante desconhecidos. O objetivo deste trabalho era medir a resistência do desgaste abrasivo de seis resinas compostas vendidas no mercado brasileiro polimerizadas com tempos de 10, 20 e 40 segundos. O método do disco retificado modificado para aplicações em odontologia foi usado para tornar esta proposta viável. Neste banco de ensaios um disco dinâmico, revestido por porcelana, desgasta um disco estático revestido do tipo de resina que se pretende avaliar, que foi polimerizada durante um tempo pré-estabelecido. Com a determinação do desgaste de material, num determinado tempo, determinava-se a agressividade (capacidade de um material para desgastar outro material) do disco dinâmico sobre o disco estático. Utilizando-se para isso um programa computacional (LabView). Posteriormente era feita a regressão linear dos valores obtidos e determinado o coeficiente angular, utilizado no cálculo de agressividade. Valores elevados de agressividade indicam uma maior agressão do disco dinâmico contra o disco estático. Os resultados mostraram um comportamento variável para cada material que foi polimerizado nos diferentes tempos de polimerização utilizado, mostrando que o método para fazer estudos de desgaste é prático e rápido para testar materiais novos antes da sua utilização.1317787Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Não temIn the current market an increasing quality is demanded to manufacture products. At the odontologic market the composed resins are becoming more and more used to replace old materials, like amalgamates in the aesthetic and functional restorations, since they present a better appearance and easier manuscript. The chemical composition of these materials varies and the results of the chemical reactions of polymerization processes are quite unknown. The aim of this work was to measure the resistance of the abrasive wear of six composed resins sold in Brazilian market when displayed to polymerization periods of 10, 20 and 40 seconds. The grinding disc method appropriated for odontology was used to make this process possible. For this a bank of assays in which a porcelain covered dynamic disc consumes a static disc recovered by the polymerized resin is used to demonstrate the method in a pre-established time. The abrasive wear was determined by the calculation of the aggressiveness (capacity of a material to consume another). This aggressiveness is determined by an initial graph of displacement for time, through the computational method (LabView program). After they have passed through a linear regression the results give as a possibility the angular coefficient, considered a parameter at the calculation of aggressiveness. Higher values of aggressiveness which means a higher aggression suffered by the resin disc indicate worse resistance to the abrasive consuming of this resin in relation to porcelain. The results showed a variable comportment for each material ahead the different polymerization time, which prove the importance in create a practical and fast analyses method to test new materials before their us

Transplant options for patients with diabetes and advanced kidney disease: a review

Optimal glycemic control in kidney transplant recipients with diabetes is associated with improved morbidity and better patient and allograft survival. Transplant options for patients with diabetes requiring insulin therapy and chronic kidney disease who are suitable candidates for kidney transplantation should include consideration of beta-cell replacement therapy: pancreas or islet transplantation. International variation related to national regulatory policies exists in offering one or both options to suitable candidates and is further affected by pancreas/islet allocation policies and transplant waiting list dynamics. The selection of appropriate candidates depends on patient age, coexistent morbidities, the timing of referral to the transplant center (predialysis versus on dialysis) and availability of living kidney donors. Therefore, early referral (estimated glomerular filtration rate < 30 mL/min/1.73 m(2)) is of the utmost importance to ensure adequate time for informed decision making and thorough pretransplant evaluation. Obesity, cardiovascular disease, peripheral vascular disease, smoking, and frailty are some of the conditions that need to be addressed before acceptance on the transplant list, and ideally before dialysis becoming imminent. This review offers insights into selection of pancreas/islet transplant candidates by transplant centers and an update on posttransplant outcomes, which may have practice implications for referring nephrologists.Diabetes mellitus: pathophysiological changes and therap

Human macrophages differentiated in the presence of vitamin D3 restrict dengue virus infection and innate responses by downregulating mannose receptor expression

ABSTARCT: Severe dengue disease is associated with high viral loads and overproduction of pro-inflammatory cytokines, suggesting impairment in the control of dengue virus (DENV) and the mechanisms that regulate cytokine production. Vitamin D3 has been described as an important modulator of immune responses to several pathogens. Interestingly, increasing evidence has associated vitamin D with decreased DENV infection and early disease recovery, yet the molecular mechanisms whereby vitamin D reduces DENV infection are not well understood. METHODS AND PRINCIPAL FINDINGS: Macrophages represent important cell targets for DENV replication and consequently, they are key drivers of dengue disease. In this study we evaluated the effect of vitamin D3 on the differentiation of monocyte-derived macrophages (MDM) and their susceptibility and cytokine response to DENV. Our data demonstrate that MDM differentiated in the presence of vitamin D3 (D3-MDM) restrict DENV infection and moderate the classical inflammatory cytokine response. Mechanistically, vitamin D3-driven differentiation led to reduced surface expression of C-type lectins including the mannose receptor (MR, CD206) that is known to act as primary receptor for DENV attachment on macrophages and to trigger of immune signaling. Consequently, DENV bound less efficiently to vitamin D3-differentiated macrophages, leading to lower infection. Interestingly, IL-4 enhanced infection was reduced in D3-MDM by restriction of MR expression. Moreover, we detected moderate secretion of TNF-α, IL-1β, and IL-10 in D3-MDM, likely due to less MR engagement during DENV infection. CONCLUSIONS/SIGNIFICANCE: Our findings reveal a molecular mechanism by which vitamin D counteracts DENV infection and progression of severe disease, and indicates its potential relevance as a preventive or therapeutic candidate

Status Report Of The Schenberg Gravitational Wave Antenna

Here we present a status report of the Schenberg antenna. In the past three years it has gone to a radical upgrading operation, in which we have been installing a 1K pot dilution refrigerator, cabling and amplifiers for nine transducer circuits, designing a new suspension and vibration isolation system for the microstrip antennas, and developing a full set of new transducers, microstrip antennas, and oscillators. We are also studying an innovative approach, which could transform Schenberg into a broadband gravitational wave detector.3631Aguiar, O.D., (2002) Class. Quantum Grav., 19, p. 1949Aguiar, O.D., (2004) Class. Quantum Grav., 21, pp. S457Aguiar, O.D., (2005) Class. Quantum Grav., 22, pp. S209Aguiar, O.D., (2006) Class. Quantum Grav., 23, pp. S239Aguiar, O.D., (2008) Class. Quantum Grav., 25, p. 114042Costa, C.A., (2008) Class. Quantum Grav., 25, p. 184002Johnson, W.W., Merkowitz, S.M., (1993) Phys. Rev. Lett., 70, p. 2367Coccia, E., Lobo, J.A., Ortega, J.A., (1995) Phys. Rev. D, 52, p. 3735Thorne, K.S., (1978) Phys. Rev. Lett., 40, p. 667Tobar, M.E., Ivanov, E.N., Blair, D.G., (2000) Gen. Rel. Grav., 32, p. 1799De Waard, (2005) Class. Quantum Grav., 22, pp. S215Vinet, J.-Y., (2010) Research in Astron Astrophys., 10, p. 956Costa, C.A., Aguiar, O.D., Magalhães, N.S., (2004) Class. Quantum Grav., 21, pp. S827Forward, R.L., (1971) Gen. Rel. Grav., 2, p. 149Eardley, D.M., Lee, D.L., Lightman, A.P., Wagoner, R.V., Will, C.M., (1973) Phys. Rev. Lett., 30, p. 884Bianchi, M., Coccia, E., Colacino, C.N., Fafone, V., Fucito, F., (1996) Class. Quantum Grav., 13, p. 2865Andrade, L.A., (2009) Microwave and Optical Tech. Lett., 51, p. 1120Furtado, S.R., (2012), in preparationIvanov, E.N., Hartnett, J.G., Tobar, M.E., (2000) IEEE Trans. Ultrason., Ferroelect., Freq. Contr., 47, p. 1526Pimentel, G.L., (2008) J. Phys. Conf. Series, 122, p. 012028Aguiar, (2009) Int. J. Modern Phys. D, 18, p. 2317Furtado, S.R., (2009), Ph.D. Thesis at INPE, not publishedBraginsky, V.B., Vorontsov, Y.I., Thorne, K.S., (1980) Science, 209, p. 547Thorne, K.S., The Quantum Limit for Gravitational-Wave Detectors and Methods of Circumventing It (1979) Sources of Gravitational Waves, p. 49. , ed. L L Smarr, Cambridge University Press, Cambridge, US

Measurement of CP observables in B± → D(⁎)K± and B± → D(⁎)π± decays

Measurements of CP observables in B ± →D (⁎) K ± and B ± →D (⁎) π ± decays are presented, where D (⁎) indicates a neutral D or D ⁎ meson that is an admixture of D (⁎)0 and D¯ (⁎)0 states. Decays of the D ⁎ meson to the Dπ 0 and Dγ final states are partially reconstructed without inclusion of the neutral pion or photon, resulting in distinctive shapes in the B candidate invariant mass distribution. Decays of the D meson are fully reconstructed in the K ± π ∓ , K + K − and π + π − final states. The analysis uses a sample of charged B mesons produced in pp collisions collected by the LHCb experiment, corresponding to an integrated luminosity of 2.0, 1.0 and 2.0 fb −1 taken at centre-of-mass energies of s=7, 8 and 13 TeV, respectively. The study of B ± →D ⁎ K ± and B ± →D ⁎ π ± decays using a partial reconstruction method is the first of its kind, while the measurement of B ± →DK ± and B ± →Dπ ± decays is an update of previous LHCb measurements. The B ± →DK ± results are the most precise to date

Search for the doubly heavy baryon Ξbc+\it{\Xi}_{bc}^{+} decaying to J/ψΞc+J/\it{\psi} \it{\Xi}_{c}^{+}

A first search for the $\it{\Xi}_{bc}^{+}\to J/\it{\psi}\it{\Xi}_{c}^{+}$ decay is performed by the LHCb experiment with a data sample of proton-proton collisions, corresponding to an integrated luminosity of $9\,\mathrm{fb}^{-1}$ recorded at centre-of-mass energies of 7, 8, and $13\mathrm{\,Te\kern -0.1em V}$. Two peaking structures are seen with a local (global) significance of $4.3\,(2.8)$ and $4.1\,(2.4)$ standard deviations at masses of $6571\,\mathrm{Me\kern -0.1em V\!/}c^2$ and $6694\,\mathrm{Me\kern -0.1em V\!/}c^2$, respectively. Upper limits are set on the $\it{\Xi}_{bc}^{+}$ baryon production cross-section times the branching fraction relative to that of the $B_{c}^{+}\to J/\it{\psi} D_{s}^{+}$ decay at centre-of-mass energies of 8 and $13\mathrm{\,Te\kern -0.1em V}$, in the $\it{\Xi}_{bc}^{+}$ and in the $B_{c}^{+}$ rapidity and transverse-momentum ranges from 2.0 to 4.5 and 0 to $20\,\mathrm{Ge\kern -0.1em V\!/}c$, respectively. Upper limits are presented as a function of the $\it{\Xi}_{bc}^{+}$ mass and lifetime.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-005.html (LHCb public pages